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ID #1076

Gamma-Butyrolactone(GBL) Quickview

GBL is the abbreviation of "gamma-Butyrolactone" which is also called γ-Butyrolactone/Dihydrofuran-2(3H)-one/Butyrolactone/1,4-Lactone/4-Butyrolactone/4-Hydroxybutyric acid lactone/gamma-Hydroxybutyric acid lactone.

γ-Butyrolactone (GBL) is a hygroscopic colorless, water-miscible liquid with a weak characteristic odor. It is the simplest 4-carbon lactone. It is mainly used as an intermediate in the production of other chemicals, e.g. methyl-2-pyrrolidone. In humans GBL acts as a prodrug for γ-hydroxybutyric acid (GHB), and it is used as a recreational CNS depressant with effects similar to those of barbiturates.

Chemistry Properties

Preferred IUPAC name: Oxolan-2-one

CAS Number: 96-48-0

Chemical formula: C4H6O2

Appearance: Colorless liquid

Density:1.1286 g/mL (15 °C), 1.1296 g/mL (20 °C)

Melting point: −43.53 °C (−46.35 °F; 229.62 K)

Boiling point: 204 °C (399 °F; 477 K)

Solubility in water: Miscible

Gamma-Butyrolactone(GBL) Quickview Uses

Gamma-Butyrolactone (GBL) has widespread industrial use. It is a common solvent found in

  • paint strippers
  • nail polish removers
  • stain removers
  • circuit board cleaners

It is also a common intermediate in industrial chemistry including the manufacture of pyrrolidones and in some pharmaceuticals.

  • GHB
  • butanediol

GBL Pharmacology

GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB.

Legal status

Australia: GBL is not classified as a drug but as a health-endangering substance. Although legislation to enter into force on 1 April 2011 will make it possible to handle narcotics for industrial purposes will enable GBL and 1,4-Butanediol to be classified as controlled substances.

Canada: GBL is a Controlled Substance under Schedule VI of the "Controlled Drugs and Substances Act" in Canada. Schedule VI of the "Controlled Drugs and Substances Act" requires vendors to collect information regarding purchases of GBL. The Act also prohibits the import and export of GBL into or out of Canada classifying it as either an indictable offense punishable with up to 10 years in prison or an offense punishable on summary conviction liable to imprisonment for up to eighteen months. It is not illegal for an individual to possess GBL in Canada.

Germany: GBL is not listed in the narcotics law, but its distribution is controlled. Possession is not illegal, but may be punished according to the Medicines Act, when intended to be sold for human consumption or synthesis of GHB. In recent years, an increase of GBL consumption has been observed due to the prohibition of GHB.

Hong Kong SAR: GBL is a dangerous drug controlled under Schedule 1 of the Dangerous Drugs Ordinance, Cap.134 (with exemption clause at Paragraph 16D). Any person who is found to have in his possession of it not in accordance with this Ordinance can be liable, on conviction upon indictment, a fine of HK$1,000,000 and to imprisonment for 7 years.

Israel: GBL was classified as a proscribed substance from 2007.

Netherlands: GBL is unlike GHB not listed in the narcotics law, but its distribution is controlled. Possession is not illegal but may be punished according to the Medicines Act, when intended to be sold for human consumption or synthesis of GHB.

Poland: GBL is classified as a drug. A license is mandatory for the manufacture, processing, reworking, importing, distribution of GBL.

Russia: GBL has been classified as a psychotropic substance since 22 February 2012. Its trafficking is limited, and non-licensed selling, buying or any other use is punishable by imprisonment up to 20 years.

Sweden: GBL is not classified as a drug but as a health-endangering substance. Although recently passed legislation to enter into force on 1 April 2011 will make it possible to handle narcotics for industrial purposes will enable GBL and 1,4-Butanediol to be classified as controlled substances.

United Kingdom: Because of their legitimate uses, regulation 4B of the 2001 regulations makes it lawful to import, export, produce, supply, offer to supply or possess GBL and 1,4-BD. Except where a person does so knowing or believing that they will be used for the purpose of human ingestion.

United States: GBL is regulated as a List I controlled chemical. As a GHB analog, it is also treated as a controlled substance under Schedule I of the Controlled Substances Act if intended for human consumption. Sales and distribution of this product for industrial use is tightly regulated and requires quantity tracing, lock and key storage and 24 hour surveillance. In 2012, manufactures moved away from outside sale of this chemical for industrial use and removed all distributors of this product due to tight regulations. Industrial purchasing of this product is only possible direct through manufacturers now of Ashland Chemical and Shrieve Chemical Company.

GBL Drug uses

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Best Pure GBL 2012-09-01 15:03